Cefixime (Antibiotic)

                Cefixime is a third generation cephalosporin antibiotic used to treat infections caused by bacteria such as pneumonia; bronchitis; gonorrhea; and ear, lung, throat, and urinary tract infections. Antibiotics will not work for colds, flu, or other viral infections.

Mechanism of Action
The bactericidal action of Cefixime is due to the inhibition of cell wall synthesis. It binds to one of the penicillin binding proteins (PBPs) which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption
Only 40-50% is absorbed from the GI tract (oral). Rate may be decreased if taken with food. Absorption from oral suspensions than tablet is more.
Distribution
It has high concentrations in bile and urine. It can cross the placenta and its protein binding capacity is 65%.
It is always better to perform appropriate cultures and susceptibility studies to determine the causative organism and its sensitivity to cefixime.

Uses
Cefixime comes as a tablet and liquid to take by mouth. It is usually taken once a day or every 12 hours (twice a day) for 5-14 days. Gonorrhea may be treated in 1-10 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cefixime exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
The uses of Cefixim are as follows :
√ Urinary Tract Infection
√ Otitis Media
√ Tonsillitis/Pharyngitis
√ Bronchitis
√ Gonococcal Infection - Uncomplicated
√ Gonococcal Infection - Disseminated
√ STD Prophylaxis

Side Effects 
☞ Upset stomach
☞ Diarrhoea
☞ Vomiting
☞ Mild skin rash
☞ Headache
☞ Skin rash
☞ Itching
☞ Hives
☞ Difficulty breathing or swallowing
☞ Wheezing
☞ Vaginal infection

Contraindications
1. Mild to Moderate Kidney Impairment
2. Clostridium Difficile Bacteria Related Colitis
3. Allergies : CEPHALOSPORINS BETALACTAMS

Pregnancy Warnings
Cefixime has been assigned to pregnancy category B by the FDA. Animal studies failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Cefixime is only recommended for use during pregnancy when benefit outweighs risk.