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              Rosuvastatin is a prescription medication used to treat high cholesterol and prevent heart attacks and strokes. Rosuvastatin belongs to a class of drugs called "statins". Rosuvastatin comes as a tablet and a capsule. It works in two ways. Rosuvastatin works by blocking an enzyme in the liver called HMG-CoA reductase, which leads to the liver making less cholesterol. It also works by increasing the liver's uptake of cholesterol from your blood and its breakdown.

Mechanism Of Action

The mechanism of action of rosuvastatin is inhibition of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase. This enzyme is the rate-limiting step in cholesterol synthesis, which reduces the production of mevalonic acid from HMG-CoA. Furthermore, this results in an increase of low-density lipoprotein receptors on hepatocyte membranes and stimulation of low-density lipoprotein catabolism. HMG-CoA reductase inhibitors also decrease levels of high sensitivity C-reactive protein (CRP). They also possess pleiotropic properties, including inhibition of platelet aggregation, anticoagulant effects, reduced inflammation at the site of a coronary plaque, and improved endothelial function.

Indications

Rosuvastatin (Crestor) is commonly used to lower bad cholesterol levels (LDL-C) and fats (triglycerides) in the blood. It also increases good cholesterol levels (HDL). Improving your cholesterol levels helps decrease your risk of heart disease, stroke, and heart attack. Rosuvastatin may also be used for other conditions as determined by your healthcare provider.

Contraindications

🅐 Allergic to rosuvastatin calcium or any of the ingredients in your rosuvastatin tablet or capsule.

🅑 Pregnancy (pregnancy category X) 

🅒 Breastfeeding 

🅓 Active liver disease 

🅔 Unexplained persistent elevations of serum transaminases

Most common side effects

■ Headache 

■ Muscle aches and pains 

■ Abdominal pain 

■ Weakness 

■ Nausea

Adverse Effects

● Creatinine kinase of greater than ten times the upper limit of normal 

● Severe myopathy 

● Rhabdomyolysis 

● AST or ALT elevations of greater than three times the upper limit of normal 

● Renal failure

● Rare adverse effects include diabetes mellitus, hematuria, proteinuria, and hypersensitivity.

Source

1. Drugs.com : Rosuvastatin

2. National Library of Medicine

3. WebMD : Rosuvastatin (Crestor) - Uses, Side Effects, and More