Friday, March 18, 2016

Lisinopril (ACE inhibitor)

                Lisinopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Lisinopril is used to treat high blood pressure (hypertension) or congestive heart failure. It is also used to improve survival after a heart attack.

Mechanism Of Action
Renin, synthesized by the kidneys, is released into the circulation where it acts on a plasma precursor to produce angiotensin I, which is converted by angiotensin-converting enzyme to angiotensin II, a potent vasoconstrictor that also causes release of aldosterone from the adrenals. Lisinopril blocks the conversion of angiotensin I to angiotensin II, leading to decreased BP, decreased aldosterone secretion, a small increase in serum potassium levels, and sodium and fluid loss.

Indications
1. Hypertension
2. Congestive Heart Failure
3. Myocardial Infarction
4. Diabetic Nephropathy
Contraindication
1. Kidney disease (or if you are on dialysis)
2. Liver disease
3. Diabetes
4. High levels of potassium in your blood.

Adverse Effects
- Headache
- Dizziness
- Insomnia, fatigue
- Gastric irritation
- Chest pain
- Itching
- Tired feeling
- Loss of appetite
- Dark urine


References
1. www.drugs.com
2. http://www.doctorslounge.com/
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2 comments:

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